Endometrial polyps may have an inflammatory origin.

Abstract

Goal: The most common gynaecological pathology is endometrial polyps. Although endometrial polyps and chronic
endometritis (CE) sometimes coexist, the formation of endometrial polyps (EP) is thought to be associated with aberrant
hormonal signalling. The objective of this research was to assess the expression of TGFβ and VEGF isoforms in the
endometrium from the contralateral side of the cavity and in the epithelium and stromal cells from endometrial polyps (P)
in women with or without indications of CE.
Study design: case-control, Academic Center is the setting.
Patients: Based on the results of the hysteroscopy, 46 women who were referred for the procedure were split into two
groups. Group B had polyps and symptoms of CE, whereas Group A had endometrial polyps and a normal controlateral
endometrium.
Interventions include endometrial biopsies, polypectomy, and office hysteroscopy.
Immunohistochemical analysis of VEGF, TGFβ1, TGFβ2, and TGFβ3 expression is the primary outcome measure.
Findings: Compared to stromal cells, the glandular epithelium produced higher VGEF, TGFβ1, and TGFβ2. Women with
CEhad greater amounts of VGEF and TGFβ1 than women without CE, and polyps had higher levels than the contralateral
endometrium. Conversely, there were no intergroup variations in TGFβ1 and TGFβ2 expression in the stroma. TGFβ3,
however, was markedly overexpressed in polyps from group B but not from group A, especially in the stromal cells that
exhibited "spindle cell" traits